Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients

  1. Chien-Fang Huanga
  2. Tsai-Chung Lic
  3. Cheng-Chieh Lina
  4. Chiu-Shong Liua
  5. Hung-Chang Shihb
  6. Ming-May Laia
  1. Department of Family Medicine
  2. Clinical Laboratory, China Medical University Hospital
  3. Department of Institute of Chinese Medicine & Public Health, China Medical University, Taichung, Taiwan, Republic of China
  1. Correspondence to Ming-May Lai, Department of Family Medicine, China Medical University Hospital, No. 2 Yuh Der Road Taichung, Taiwan, Republic of China Tel: +886 4 22052121 ext. 4507/4508; fax: +886 4 22033986; e-mail: laimm@www.cmuh.org.tw


Background Several lipid ratios may be predictors of coronary artery disease risk. We assessed the efficacy of Monascus purpureus Went rice (red yeast rice) on lowering lipid ratios.

Method and results We evaluated 79 hypercholesterolemic patients (aged 23-65 years) who received a twice-daily dose of either red yeast rice or a placebo at 600 mg for 8 weeks. The 8-week treatment with red yeast rice showed significantly greater reduction than the placebo treatment in low-density lipoprotein cholesterol levels, total cholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and apolipoprotein B/apolipoprotein A-I ratios.

Conclusions Red yeast rice can reduce lipid ratios in hypercholesterolemic patients.


  • Received June 13, 2006.
  • Accepted November 30, 2006.


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